Targeting the centromedian thalamic nucleus for deep brain stimulation

AEL Warren; LJ Dalic; W Thevathasan; A Roten; KJ Bulluss; J Archer

Journal article

Targeting the centromedian thalamic nucleus for deep brain stimulation

AEL Warren, LJ Dalic, W Thevathasan, A Roten, KJ Bulluss, J Archer

Journal of Neurology Neurosurgery and Psychiatry | BMJ PUBLISHING GROUP | Published : 2020

DOI: 10.1136/jnnp-2019-322030

Abstract

Objectives: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox-Gastaut syndrome (LGS). We aimed to improve neurosurgical targeting of the CM by: (1) developing a structural MRI approach for CM visualisation, (2) identifying the CM's neurophysiological characteristics using microelectrode recordings (MERs) and (3) mapping connectivity from CM-DBS sites using functional MRI (fMRI). Methods: 19 patients with LGS (mean age=28 years) underwent presurgical 3T MRI using magnetisation-prepared 2 rapid acquisition gradient-echoes (MP2RAGE) and fMRI sequences; 16 patients proceeded to..

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University of Melbourne Researchers

Aaron Warren Author

Linda Dalic Author

Wesley Thevathasan Author

Kristian Bulluss Author

Related Projects (1)

DEEP BRAIN STIMULATION FOR SEVERE GENERALISED EPILEPSY OF LENNOX-GASTAUT PHENOTYPE

Deep Brain stimulation (DBS) is an emerging treatment for epilepsy, recently approved for use in Australia on the basis of trials in focal e..

Grants

Awarded by BC Children’s Hospital Foundation

Funding Acknowledgements

This study was supported by a project grant from the National Health and Medical Research Council of Australia (grant number 1108881) and a seed grant (grant number 2634) from the Rare Disease Foundation (www.rarediseasefound ation.org) and the British Columbia Children's Hospital Foundation (www.bcchf.ca).AELW was supported by a Postdoctoral Fellowship from the LGS Foundation (www.lgsfoundation.org).